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Image Search Results
Journal: Translational Neurodegeneration
Article Title: A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease
doi: 10.1186/s40035-024-00439-4
Figure Lengend Snippet: Correlations of plasma mid-p-tau or N-p-tau level with tau or amyloid PET in the subjects with AD continuum. a The correlation between plasma mid-p-tau181 level and 18 F-florzorotau tau PET is depicted through its topographical representation ( P < 0.05, FWE-corrected). b , c Scatter plots of the correlation between plasma mid-p-tau181 level and tau PET tracer accumulation in each ROI. Pearson's correlation analysis was employed to calculate the r and P values. Statistical significance was established at P < 0.0125, corrected for multiple comparisons using the Bonferroni method. Regression analysis, indicated by a straight or curved line, depicts the preferred model, with its goodness of fit quantified using the R 2 value. d Topographical representation of the correlation between plasma N-p-tau181 level and tau PET ( P < 0.05, uncorrected). e , f Scatter plots of the correlation between plasma N-p-tau181 level and tau PET tracer accumulation in each ROI. The procedure for the correlation analysis was the same as that in b and c . g Topographical representation of the correlations of each plasma p-tau181 assay with amyloid- (left column) and tau- (right column) PET in the CN and AD continuum cohort ( P < 0.05, FWE-corrected). h Bar graphs illustrating beta coefficient values of amyloid and tau PET in multiple liner regression analysis with each p-tau assay. * P < 0.05, ** P < 0.005, **** P < 0.0005. P -values were corrected for multiple comparisons using Bonferonni correction with the number of explanatory variables
Article Snippet: Conversely, the conventional N-p-tau181 assay (
Techniques: